Insulin resistance: vascular function and exercise

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Insulin resistance: vascular function and exercise

Insulin resistance associated with metabolic syndrome and Type 2 diabetes mellitus is an epidemic metabolic disorder, which increases the risk of cardiovascular complications. Impaired vascular endothelial function is an early marker for atherosclerosis, which causes cardiovascular complications. Both experimental and clinical studies indicate that endothelial dysfunction in vasculatures occurs...

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Vascular and Platelet Function in Insulin Resistance

This thesis is based on the following original publications, which are referred to in the text by their Roman numerals.

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Endothelial Function Varies According to Insulin Resistance Disease Type Short Title: Insulin Resistance and Vascular Function

Objective: We examined the relationship between insulin resistance and vascular function in three insulin resistant states (type 2 diabetes mellitus, non-HIV lipodystrophic diabetes, and non-diabetic polycystic ovary syndrome (PCOS)) and in healthy controls. Research Design and Methods: The population included 12 women with type 2 diabetes, 6 with lipodystrophic diabetes, 10 with polycystic ova...

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Insulin resistance and exercise tolerance in heart failure patients: linkage to coronary flow reserve and peripheral vascular function

BACKGROUND Insulin resistance has been linked to exercise intolerance in heart failure patients. The aim of this study was to assess the potential role of coronary flow reserve (CFR), endothelial function and arterial stiffness in explaining this linkage. METHODS 39 patients with LVEF < 35% (median LV ejection fraction (LVEF) 31 (interquartile range (IQ) 26-34), 23/39 of ischemic origin) unde...

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Vascular Insulin Resistance Through Fat

Endothelial dysfunction comprises a number of functional alterations in the vascular endothelium that are associated with diabetes and cardiovascular disease, including changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation and altered barrier function. Hyperglycemia is a characteristic feature of type 1 and type 2 diabetes and plays a pivotal r...

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ژورنال

عنوان ژورنال: Integrative Medicine Research

سال: 2016

ISSN: 2213-4220

DOI: 10.1016/j.imr.2016.06.001